the prairie doc

Vaccines when money is no object

Posted

I’ve been spending a lot of time talking with patients about the COVID-19 vaccine. Sometimes, we celebrate it, some are skeptical and others are not convinced they can trust the vaccine.

When I talk to the first group, we chat about our plans to reunite with people and activities we love. With the second group, I share stories of my firsthand experiences as a doctor during this crisis. We talk about interpreting death rates, how death certificates are filled out or how health care is reimbursed.

I particularly enjoy the conversations with the third group, many of whom share some of the same questions I had. I did not believe, at the beginning of the pandemic, we could possibly have a vaccine by the end of 2020.

There are two lessons beautifully illustrated by the lightning-fast development of the COVID-19 vaccines. The first is what can happen when money is no object. The typical process of drug development involves a relatively small investment for initial testing, investing a little more only if those results are encouraging, rinse and repeat. With the COVID-19 vaccines, all needed funding was available almost immediately.

The second lesson is the importance of past research. Other coronaviruses caused outbreaks of SARS (severe acute respiratory syndrome) in 2003 and MERS (Middle East respiratory syndrome) in 2012. Researching these deadly infections taught us how coronaviruses invaded human cells, so we knew that the spike protein was a good target for a vaccine. Developing a vaccine for Ebola taught us how to safely edit the genes of a less harmful virus and use it to teach our immune systems to fight a more serious infection. Thirty years of mRNA research led to clinical trials of mRNA-based cancer therapies, and investigation of mRNA vaccines for influenza, rabies, and Zika.

Chinese scientists published the genetic code for the virus in January 2020. Within days, using all that previous knowledge, researchers began production of vaccines. When the clinical trials began, the pandemic was raging, and many trial participants were exposed to COVID-19 over a short period of time. Trials could proceed faster than usual because when lots of people are getting sick, it doesn’t take as much time to determine if a therapy, including a vaccine, is effective.

Were the COVID-19 vaccines developed in record time? Yes, because money was no object, and because 30 years of scientific research and development left us poised to succeed.

Comments

No comments on this story | Please log in to comment by clicking here
Please log in or register to add your comment